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The deleterious impact of early feeding practices on infantile growth and health is well known. This paper reviews possible biological and developmental correlates of these effects. With regard to the impact of the early feeding practices on the organization of the central nervous system, both maturational and sensitization effects may be involved. A maturational hypothesis is presented to explain the deleterious impact of early feeding practices on motor activity. Long-term consequences of early feeding may be present in later neuroendocrine functions. With regard to biological changes affecting the immune system, the hypothesis of allostatic load is described. It is suggested that the deleterious consequences of early feeding on child growth may also be explained by developmental processes that take place early in life, such as the establishment of optimal intrauterine conditions. These observations support the importance of the early environment in the onset and the course of the disease. In order to prevent or to delay the deleterious consequences of early feeding practices, it is important to improve the knowledge on the pathways involved.A new genetic analysis be359ba680
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